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Phosphaturic Mesenchymal Tumors in Osteomalacia


The causes of osteoporosis are unknown, but certain lifestyle habits and nutritional deficiencies increase the risk of developing it. Physical activity is essential to bone health as it helps maintain bone density. However, a sedentary lifestyle harms bone health and may lead to osteoporosis. A doctor can diagnose osteoporosis using blood and urine tests for calcium and phosphorus levels. An x-ray will also look for structural changes.

Vitamin D deficiency

Vitamin D deficiency is an essential factor in the development of osteomalacia. This disease results in bone pain, skeletal deformity, proximal muscle weakness, and fracture. It frequently coexists with osteoporosis and aggravates it. Vitamin D deficiency is also associated with an increased risk of cancer, depression, and schizophrenia. Vitamin D therapy may be beneficial in treating these conditions.

In the present study, two patients with osteomalacia following radiation therapy were treated successfully with vitamin D supplements and sun exposure. Both patients had histological and serological evidence of vitamin D deficiency. After the combined treatment, both patients improved. The authors also reviewed the relevant literature and recommended that serum vitamin D levels be included in diagnostic tests in patients with minor bowel damage.

Vitamin D is necessary for normal skeleton development. Deficiency affects calcium metabolism, osteoblastic activity, matrix ossification, and bone density. It impairs the mineralization phase of bone remodeling and increases the replacement of unmineralized osteoid. However, the exact relationship between Vitamin D and bone mineral density is unknown.

Phosphaturic mesenchymal tumors

This study presents three cases of phosphaturic mesenchymal tumors in patients with osteomalacia. All three patients had non-localized, non-malignant PMTs. The tumors were detected using magnetic resonance imaging (MRI), and positron emission tomography (PET) scans. The pathology reports confirmed the diagnosis of phosphaturic mesenchymal tumors of the spinal region. The patients underwent surgical resection of the mass in the posterior L5 region with bone cement reconstruction, L4-S1 spinal canal decompression, and L3-S2 internal fixation. In addition, they were treated for hypophosphatemia. As a result, the patient’s condition improved, and the serum phosphorus levels returned to normal.

The tumors usually occur in adults, although pediatric cases have also been described. In most cases, PMTs are located in the soft tissues surrounding the extremities, while 5% develop in the head and neck. The most common tumor sites in the craniofacial region are the nose and paranasal sinuses. In rare cases, the tumors are located in the jaw, which is very uncommon. Because of the rarity of this disorder, it is essential to consider this diagnosis for any patient with osteomalacia.

Lifestyle changes

Osteomalacia is a bone disease resulting from changes in vitamin D and calcium metabolism. This results in poorer bone formation and mineralization. It also leads to decreased absorption of calcium in the intestines. It affects women and older adults, particularly those with dark skin.

Lifestyle changes for osteomalacia may include increasing the intake of vitamin D and calcium supplements, which are essential for bone health. In addition, patients may need additional calcium or phosphorus supplements. Medications to regulate vitamin D metabolism may also be prescribed. Dietary changes may also be necessary. If the cause of osteomalacia is unclear, you may need to consult a rheumatologist or endocrinologist.

In some cases, lifestyle changes for osteomalacia can prevent or reverse the disease. Increasing vitamin D intake is essential for preventing osteomalacia. Foods high in vitamin D include oily fish, eggs, and yogurt. You can also fortify food items with vitamin D, such as milk, bread, and yogurt.


The treatment of osteomalacia focuses on reversing the disorder, which can be caused by vitamin D deficiency or improper mineralization of the osteoid. This disorder affects the bone’s ability to absorb calcium and phosphorus. Therefore, treatment should include increasing vitamin D, calcium, and phosphate intake.

Osteomalacia is most often seen in children and is characterized by the marked softening of bones. It can lead to bowing during growth, and, in young adults and older adults, it can lead to fractures. Treatment for osteomalacia should focus on providing the affected individual with adequate amounts of vitamin D and should be geared toward treating any underlying disorders. Symptoms include bone pain and muscle weakness.

Treatment for osteomalacia may include dietary changes and increased exposure to sunlight. These changes will strengthen the bones and muscles, reducing symptoms.